VegaMC - VegaMC: A Package Implementing a Variational Piecewise Smooth
Model for Identification of Driver Chromosomal Imbalances in
Cancer
This package enables the detection of driver chromosomal
imbalances including loss of heterozygosity (LOH) from array
comparative genomic hybridization (aCGH) data. VegaMC performs
a joint segmentation of a dataset and uses a statistical
framework to distinguish between driver and passenger mutation.
VegaMC has been implemented so that it can be immediately
integrated with the output produced by PennCNV tool. In
addition, VegaMC produces in output two web pages that allows a
rapid navigation between both the detected regions and the
altered genes. In the web page that summarizes the altered
genes, the link to the respective Ensembl gene web page is
reported.